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Healthy AF | Healthy After 50: Daily Summaries Delivered
by Zane Griggs: Health Tips
Healthy AF, the podcast dedicated to helping you live a healthier life after the age of 50, hosted by health and longevity expert Zane Griggs. This show is your guide to achieving optimal health, both physically and mentally. Whether you're in your 20s and want to plan for a healthy future or in your 50s and seeking to catch up, this show could help you improve your nutrition, fitness, and overall well-being. Each week, we'll dive into the latest research and expert advice on topics such as exercise, stress management, and more. We'll discuss practical strategies for maintaining a healthy lifestyle, including how to balance your diet and stay active as you age. Remember, it's never too late to prioritize your health and become Healthy AF!
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- 3 weeks ago20 min
57. The Future of Personalized Medicine: Genetics, Biomarkers & Longevity| LIVE with Dr. Anil Bajnath at Mindshare
I sat down LIVE at Mindshare with Dr. Anil Bajnath to talk about where medicine is headed next: precision medicine, advanced biomarkers, genetics, chronic illness, longevity, and regenerative health. Dr. Bajnath is a family physician with additional training in anti-aging, regenerative, functional, and precision medicine. He founded the Institute for Human Optimization and the American Board of Precision Medicine, and his approach is built around connecting what he calls the molecular dots—from your genome to your phenotype—to understand what is actually driving an individual's health. In this conversation, we get into why two people can be exposed to the same environment and respond completely differently, how genetics and environmental exposures can interact, and why advanced testing can reveal patterns that standard labs may miss. We also talk about: Whole genome sequencing and individualized risk Chronic inflammatory response syndrome and complex illness Mold, Lyme, viral illness, and environmental exposures Detoxification pathways and pharmacogenomics Advanced biomarker testing Alzheimer's and neurodegenerative disease Therapeutic plasma exchange Hyperbaric oxygen and photobiomodulation Environmental toxicants and microplastics Ozone therapies Regenerative medicine, stem cells, and exosomes Why I like Dr. Bajnath's philosophy of letting the data drive the treatment, rather than chasing whatever health trend happens to be popular One of my favorite concepts from this conversation is his approach to P4 medicine: personalized, predictive, preventative, and participatory. This is what the future of individualized health care looks like to me: understanding the person in front of you first, then choosing the intervention. Huge thanks to Dr. Anil Bajnath for sitting down with me at Mindshare. Learn more about Dr. Bajnath: Institute for Human Optimization: https://www.ifho.org/ American Board of Precision Medicine: https://theabopm.org/ Transcript(20261019-002329) YouTube Chapters 0:00 The Future of Personalized Medicine 1:00 Inside the Institute for Human Optimization 2:00 Chronic Complex Illness & CIRS 3:00 Genetics, Environment & Chronic Inflammation 5:00 Transcriptomics: Which Genes Are Being Turned On? 6:00 Whole Genome Sequencing & Precision Medicine 8:00 Testing Beyond Standard Labs 9:00 Advanced Treatments for Complex Disease 10:00 Therapeutic Plasma Exchange & Neurodegeneration 11:00 Environmental Toxins, Microplastics & Detoxification 12:00 Ozone Therapy, NRF2 & Advanced Interventions 13:00 "Weed, Seed & Feed" Before Regenerative Medicine 14:00 Health Optimization for Executives & High Performers 15:00 P4 Medicine: Personalized, Predictive & Preventative 16:00 Stem Cells, Exosomes & Regenerative Medicine 17:00 The Future of Stem Cell Access 18:00 Where to Find Dr. Anil Bajnath
- Sep 28, 202625 min
56. The Overlooked Hormone Behind Fasting Blood Sugar | Glucagon, Cortisol & Mitochondria (Part 3)
Why is your fasting blood sugar high even when you're eating clean, training consistently, cutting sugar, or even following a low-carb diet? That's what I'm breaking down in Part 3 of this series. I've dealt with this myself. There was a period where I was eating low carb, doing intermittent fasting, training fasted, and still waking up with fasting glucose in the 90s and sometimes higher. At first glance, that doesn't make much sense. But once I started looking deeper into glucagon, cortisol, adrenaline, liver glucose production, and what happens when your cells aren't producing enough ATP, the picture changed. Your fasting blood sugar isn't just about what you ate the night before. Your liver is making glucose all night long, and hormones like glucagon, cortisol, and adrenaline help control how much gets released into the bloodstream. In this episode, I break down: Why low ATP can create a stress response How adrenaline raises blood sugar and free fatty acids How cortisol can keep gluconeogenesis running Why glucagon may be one of the most overlooked hormones in metabolic health How insulin and glucagon are supposed to regulate each other Why fasting glucose can stay elevated even on a low-carb diet How the Randle cycle can interfere with glucose oxidation Why simply cutting more carbs may lower the number without fixing the underlying issue The labs I look at beyond fasting glucose alone This connects directly back to Parts 1 and 2, where I explained how mitochondrial dysfunction can reduce ATP production even when enough calories are coming in. When that energy deficit keeps happening, your body responds like there's an emergency. And over time, that hormonal response can start showing up in your labs. If you haven't watched the first two episodes yet, go back and start there. It'll make this one much easier to follow. In Part 4, I'm going to zoom out and show how this same underlying metabolic dysfunction can show up as several different problems across the body. Subscribe and turn on notifications so you don't miss it. Stay Healthy AF, Zane Episode Timestamps: 0:00 The Overlooked Hormone Behind Fasting Blood Sugar 0:45 Zane's Own Experience With Elevated Fasting Glucose 2:00 When You're "Doing Everything Right" But Glucose Is Still High 3:00 How Seed Oils & Mitochondrial Dysfunction Fit Into the Story 5:00 Adrenaline: The First Stress Response 6:20 How Adrenaline Raises Fat & Glucose in the Blood 8:00 Why Stored Linoleic Acid Matters 8:45 Cortisol Takes Over When the Stress Doesn't Stop 10:00 Gluconeogenesis & Chronically Elevated Cortisol 12:00 Cortisol, PGC-1α & Mitochondrial Repair 13:00 Glucagon: The Overlooked Hormone 14:00 Why Low ATP Can Drive Glucagon Higher 15:00 When Insulin & Glucagon Stop Regulating Each Other 16:00 Why Your Liver Makes Glucose Overnight 17:30 The Randle Cycle Explained 19:00 Why Glucose Can Back Up in the Bloodstream 20:00 Why Cutting More Carbs May Not Fix the Problem 21:00 What Your Fasting Glucose Number Doesn't Tell You 21:40 Labs Zane Looks At 22:40 What's Coming in Part 4 23:20 Looking at the Whole Metabolic Pattern Connect with Zane Griggs: 📲 Instagram: @zanegriggsfitness 🌐 Website: <a href= "https://za
- Sep 7, 202658 min
55. Your Vision Is Trainable: How to Improve Eyesight, Focus & Brain Performance | Dr. Bryce Appelbaum
What if declining vision, eye strain, headaches, brain fog, and difficulty focusing weren't simply things you had to accept as you get older? In this episode of Healthy AF, Zane Griggs sits down with neuro-optometrist Dr. Bryce Appelbaum to explore the connection between your eyes and your brain—and why he believes vision should be trained just like the rest of your body. Dr. Appelbaum explains the important difference between eyesight and vision, how hours of daily screen time can place the visual system under stress, and why functional vision problems can sometimes produce symptoms that overlap with problems involving attention, reading, and learning. They also dive into vision after 40, reading glasses, screen-related eye strain, concussion recovery, and how Dr. Appelbaum works with professional and Olympic-level athletes to improve visual processing, peripheral awareness, reaction time, depth perception, and performance. Plus, Dr. Appelbaum walks Zane through a simple "eye push-up" exercise designed to train the focusing system and shares the 20-20-20 rule you can start using during screen-heavy days. In this episode: Eyesight vs. vision: why they're not the same thing How screen time affects the eye-brain connection Vision, attention, reading, and focus Why your distance vision may change with heavy near work The 20-20-20 rule for screen breaks Vision training for professional athletes Vision changes after concussion and head injuries Why vision matters for balance and fall prevention as we age What happens to near vision after 40 How to perform Dr. Appelbaum's eye push-ups Reading glasses and the focusing system Digital performance lenses and screen stress How to start training your vision Connect with Zane Griggs: 🧠 Free Plan: free40plan.com 📲 Instagram: @zanegriggsfitness 🌐 Website: zanegriggs.com Guest Links: ScreenFit: ScreenFit.com — use code ZANE for $200 off / 40% off My Vision First: MyVisionFirst.com Digital Performance Lenses: use code ZANE for 10% off https://myvisionfirst.com 0:00 Meet Dr. Bryce Appelbaum 1:42 Vision Problems, ADHD & Dyslexia Symptoms 2:33 Eyesight vs. Vision: What's the Difference? 3:45 Why Your Eyesight May Change With Screen Time 5:48 Can You Actually Exercise Your Vision? 6:41 What Screens Are Doing to Your Visual System 8:39 The Problem With 7+ Hours of Screen Time 10:55 How Vision Can Affect Your Stress Response 12:29 Adding "Vision Snacks" to Your Day 13:43 The 20-20-20 Rule 16:19 ScreenFit & Vision Performance Training 17:34 How Elite Athletes Train Their Vision 20:34 Concussions, Head Injuries & Vision 23:47 How Vision Training Changed an MLB Player's Performance 25:09 Does Vision Have to Decline With Age? 43:58 Why Reading Gets Harder After 40 45:53 How to Do Eye Push-Ups 50:02 The Problem With Monovision 52:26 Vision Training for Longevity 53:21 ScreenFit + Special Offer 55:02 Digital Performance Lenses 58:44 Where to Find Dr. Bryce
- Aug 31, 20260 min
54. Why Am I Always Hungry? The Mitochondrial Connection to Hunger, Cravings & Seed Oils Part 2 VIDEO
You just ate a full meal. You consumed enough calories. So why are you hungry again 45 minutes later? Or maybe it's 3 PM—you've eaten plenty, but you're running on fumes, struggling to focus, and craving something sweet or starchy. Most people blame willpower, blood sugar, or a lack of protein. In Part 2 of Zane Griggs' series on seed oils and mitochondrial health, he explores a different possibility: what if the problem isn't how much energy you're eating, but how efficiently your cells are converting that food into ATP? In this episode, Zane breaks down the difference between food energy and cellular energy, how your mitochondria convert calories into ATP, and why inefficient energy production may contribute to hunger, cravings, fatigue, brain fog, poor recovery, and stubborn body composition. He also continues the mitochondrial story from Episode 1, exploring how PUFA-rich mitochondrial membranes may contribute to proton leak and cardiolipin damage, how lipid oxidation products such as 4-HNE and MDA can interact with mitochondrial DNA, and why these processes may become increasingly relevant as we age. Zane also explains what these issues can look like in everyday life: feeling unsatisfied after meals, afternoon cravings, energy crashes, poor exercise recovery, and body composition that doesn't seem to respond proportionately to your diet and training. This is Part 2 of the Healthy AF series examining seed oils, mitochondrial function, and metabolic health. Episode Timestamps: 0:00 Why Are You Hungry Again After Eating? 1:00 Food Energy vs. Cellular Energy 2:00 Calories Have to Be Converted Into ATP 3:00 Why Low ATP Can Trigger Hunger & Cravings 4:00 How Mitochondrial Inefficiency Changes the Equation 5:00 Proton Leak: Losing Energy as Heat 6:00 Cardiolipin Damage & the Electron Transport Chain 7:00 Why Your Cells Signal You to Eat More 8:00 Hunger Isn't Always a Willpower Problem 9:00 4-HNE, MDA & Oxidative Damage 10:00 How Oxidation Can Reach Mitochondrial DNA 11:00 Why Mitochondrial DNA Damage Matters After 40 12:00 Hunger & Fatigue as Early Warning Signs 13:00 Cravings, Energy Crashes & Poor Recovery 14:00 How Much Linoleic Acid Are We Eating? 15:00 Where Seed Oils Hide in the Modern Diet 16:00 Why Some People Seem Fine Eating Seed Oils 17:00 Metabolic Problems Can Develop Over Decades 18:00 Next: Blood Sugar, Glucagon + Free Fit Over 40 Plan Connect with Zane Griggs: 🧠 Free Plan: free40plan.com 📲 Instagram: @zanegriggsfitness 🌐 Website: zanegriggs.com Research Referenced Hulbert et al. (2007) — Membrane Composition & Lifespan Seebacher et al. (2010) — Oxidative Metabolism & Proton Leak Paradies et al. (2009) — Cardiolipin Peroxidation & Mitochondrial Dysfunction Chicco & Sparagna (2007) — Cardiolipin & Mitochondrial Disease Stanley et al. (2012) — Dietary Fat & Mitochondrial Function Khairallah et al. (2012) — Membrane Fatty Acids & Mitochondrial Function Penzo et al. (2002) — Fatty Acids & Mitochondrial Function <a href= "https://pubmed.ncbi.nlm.nih
- Aug 17, 202619 min
53. What Happens to Seed Oils After You Eat Them?
What actually happens to seed oils once they enter your body? In this first episode of a new Healthy AF series, Zane Griggs breaks down the metabolic chain reaction he argues can begin when dietary polyunsaturated fats become incorporated into the membranes of your mitochondria. Your mitochondria produce the ATP that powers your cells—but the fats you eat can become part of the physical structure of the mitochondrial membrane. Zane explores research around membrane composition, polyunsaturated fats, oxidative vulnerability, proton leak, mitochondrial uncoupling, and cardiolipin. You'll learn why Zane believes the conversation around seed oils needs to go much deeper than calories or inflammation—and why mitochondrial health may be an important piece of understanding metabolic health, energy production, and longevity. Zane also discusses research suggesting mitochondrial membrane composition can change in response to dietary fat composition, meaning what your mitochondria are built from isn't necessarily fixed. This is Part 1 of Zane's deep dive into seed oils, mitochondria, and metabolic health. In the next episode, he'll explore how this chain of events may connect to hunger and why you can feel hungry even when you're consuming plenty of food. Get Zane's FREE Fit Over 40 Plan: Free40Plan.com Research & Resources Want to dig into the research behind this episode? Here are some of the studies and reviews referenced in Zane's deep dive into dietary fats, mitochondrial membranes, oxidation, and longevity: Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals — Hulbert et al. (2007) https://pubmed.ncbi.nlm.nih.gov/17928583/ Role of Cardiolipin Peroxidation and Ca²⁺ in Mitochondrial Dysfunction and Disease — Paradies et al. (2009) https://pubmed.ncbi.nlm.nih.gov/19368971/ Role of Cardiolipin Alterations in Mitochondrial Dysfunction and Disease — Chicco & Sparagna (2007) https://pubmed.ncbi.nlm.nih.gov/16899548/ Improved Mitochondrial Function with Diet-Induced Increase in DHA or Arachidonic Acid in Membrane Phospholipids — Khairallah et al. (2012) https://pmc.ncbi.nlm.nih.gov/articles/PMC3316678/ Effects of Fatty Acids on Mitochondria: Implications for Cell Death — Penzo et al. (2002) https://pubmed.ncbi.nlm.nih.gov/12206909/ Extended Longevity of Wild-Derived Mice Is Associated with Peroxidation-Resistant Membranes — Hulbert et al. (2006) https://pubmed.ncbi.nlm.nih.gov/16620917/ Modification of Fatty Acid Unsaturation, Oxidative Damage & Longevity — Pamplona et al. (2004) https://pubmed.ncbi.nlm.nih.gov/15130667/ Allometry of Mitochondrial Proton Leak: Membrane Surface Area & Fatty Acid Composition — Porter, Hulbert & Brand (1996) https://pubmed.ncbi.nlm.nih.gov/8997352/ YouTube Chapters 0:00 What Happens to Seed Oils After You Eat Them? 2:15 How Your Mitochondria Produce Energy 3:25 The Fats You Eat Become Part of Your Mitochondria 4:20 Why Polyunsaturated Fats Are More Vulnerable to Oxidation 6:40 Mitochondrial Membranes and the "Pacemaker of Aging" 8:00 How Seed Oils May Contribute to Proton Leak 10:40 Cardiolipin and the Mitochondrial Damage Cycle 14:00 What Long-Lived Species Can Teach Us About Membrane Fat 15:20 How This May Connect to Metabolic Disease 16:05 Can You Rebuild Your Mitochondrial Membranes? 17:00 What's Coming Next + Free Fit Over 40 Plan
- Jul 20, 202648 min
52. The Truth About Alcohol Nobody Wants to Hear | Sam Lander
Can you be Healthy AF if you still drink alcohol? In this episode of Healthy AF (Healthy After 50), I sit down with functional diagnostic nutritionist, peptide educator, and My Peptide University faculty member Sam Lander for one of the most honest conversations we've had on the podcast. Sam opens up about her incredible journey—from addiction, prison, and rebuilding her life—to becoming one of the most respected educators in functional medicine and peptide therapy. We dive into why so many people are doing everything "right" but still don't feel well, how functional lab testing uncovers hidden problems, and why alcohol may be the single biggest obstacle standing between you and optimal health. If you're focused on building muscle after 40, increasing energy, improving your gut, optimizing hormones, or extending your healthspan, this is an episode you don't want to miss. In this episode we discuss: • Sam's journey from addiction and prison to functional medicine • Why functional lab testing changes everything • The hidden connection between gut health and chronic symptoms • Why peptides require individualized protocols • The truth about "mommy wine culture" • How alcohol affects metabolism, inflammation and longevity • Why quitting alcohol is the biggest health hack most people ignore • Building resilience physically and mentally • Creating lasting health after 40 Connect with Sam Lander https://seefitliving.com https://www.instagram.com/seefitliving 0:00 Introduction: Meet functional diagnostic nutritionist Sam Lander 1:25 What functional diagnostic nutrition really is 2:05 Sam's childhood health struggles 3:20 Addiction begins at a young age 6:10 Prison, rock bottom, and rebuilding her life 10:45 Becoming a personal trainer after prison 15:30 Why doing "everything right" still wasn't enough 16:40 Discovering functional medicine through gut health 18:00 Why alcohol is the biggest health hack people ignore 22:30 The truth about mommy wine culture 27:40 How alcohol affects hormones, weight loss, and longevity 33:15 Peptides: why certification and protocols matter 38:20 Creating personalized health strategies instead of one-size-fits-all advice 43:10 Recovery, resilience, and building a healthier future 48:10 Final thoughts and where to connect with Sam
- Jun 4, 202640 min
51. The Seed Oil Studies Are Measuring the Wrong Thing
A new seed oil study may look reassuring at first glance — but what did it actually measure? In this episode, Zane Griggs breaks down a 2025 review of clinical studies on seed oils and explains why short-term improvements in blood markers do not necessarily tell us what is happening inside the mitochondria. You'll learn why the real concern is not only what shows up in a blood draw, but what happens when polyunsaturated fats become incorporated into mitochondrial membranes over time. Zane walks through: what the seed oil review actually found why flaxseed and sesame oil are not the same as soybean or corn oil the difference between blood markers and mitochondrial damage cardiolipin, ATP production, and oxidative stress why 4-HNE and other aldehydes matter how cooking oils change when heated why stored linoleic acid can remain in the body for years why a short-term study may miss a long-term mitochondrial problem how soybean oil consumption has changed over the last century why stable fats may matter more than most people realize Studies: Laurindo et al. Frontiers in Nutrition. 2025;12:1502815 Hulbert AJ et al. Physiological Reviews. 87:1175–1213, 2007 Seebacher F, Brand MD, Else PL, Guderley H, Hulbert AJ, Moyes CD. Physiological and Biochemical Zoology. 83(5):721–732, 2010 UC Riverside / Journal of Lipid Research, November 2025 SNI Global soybean oil consumption data The point is not to ignore studies that show short-term improvements. The point is to understand their limitations and ask whether they are measuring the outcome that actually matters. Download Zane's Free Fit Over 40 Plan: https://free40plan.com 00:00 The seed oil study everyone is going to cite 01:00 What the 2025 review actually measured 02:00 Why flaxseed and sesame oil are different 03:30 The short-term benefits are real — but limited 04:00 The problem with relying on blood markers 05:00 What happens inside the mitochondria 06:00 Cardiolipin and ATP production explained 07:00 The damage the studies did not measure 08:00 Why higher antioxidant activity can be misleading 09:00 The researchers admitted a major limitation 10:00 They did not verify the oil composition 11:00 Why processing, heat, and storage matter 12:00 Fast-food fryer oil is not the same intervention 13:00 How stored linoleic acid remains in the body 15:00 Why the control groups were not truly low-PUFA 16:00 The washout problem no short-term study solves 17:00 Comparing two versions of excess exposure 18:00 How much soybean oil Americans consume 19:00 Physiological need vs modern consumption 21:00 Why the baseline recommendation may already be too high 22:00 The UC Riverside soybean oil research 23:00 Oxylipins, liver health, and mitochondrial function 25:00 Why standard blood tests may miss the damage 26:00 The peroxidation index explained 27:00 Omega-3 vs omega-6 vs monounsaturated fats 28:00 Why more fish oil may not solve the problem 29:00 Saturated fat and mitochondrial membrane stability 31:00 What membrane fluidity actually requires 32:00 Why longer-lived species matter 33:00 What the pro-seed-oil literature can and cannot prove 35:00 Short-term blood improvements vs long-term membrane loading 36:00 What fats Zane recommends using instead 38:00 Why ingredient labels matter 39:00 Final takeaway: read the studies carefully
- Jun 2, 202658 min
50. Your Body Is Stuck Burning Fat — And It's Making You Sick (Part 2)
What happens when your body gets stuck burning fat and can't switch back to glucose? In Part 2, Zane breaks down metabolic inflexibility and explains why being locked into fat-dominant metabolism is not the same as being metabolically healthy. You'll learn how this pattern affects the muscle, heart, and liver — and how elevated fatty acids can impair glucose oxidation, disrupt insulin signaling, and contribute to insulin resistance, fatty liver disease, and heart failure. Start with Part 1 first for the ATP and glucose-efficiency breakdown. 01:00 The metabolic signature of insulin resistance 03:30 Why your body should switch between fat and glucose 06:00 The 3 tissues that reveal metabolic inflexibility 08:30 Why Zane changed his mind about low carb 13:30 The real definition of metabolic inflexibility 15:00 Why elevated blood sugar can happen on keto or carnivore 20:00 Heart failure and metabolic disease 22:00 Why failing hearts become more dependent on fat 25:00 Why glucose is not the problem 29:00 The liver and fatty liver disease 33:00 Fatty liver is a metabolic inflexibility problem 34:00 Why the liver starts producing more glucose 40:00 How liver disease progresses 41:00 The muscle, heart, and liver connection 46:00 How to restore glucose oxidation 47:00 Why high-fat, low-carb can mimic metabolic disease Kelley, D.E. (2005) "Skeletal muscle fat oxidation: timing and flexibility are everything" Journal of Clinical Investigation — JCI25758 / PMC1159159 Used for: Definition of metabolic inflexibility; experimental elevation of plasma FFAs recreating T2D metabolic signature in skeletal muscle; blunted insulin-stimulated glucose oxidation; impaired suppression of lipid oxidation Ukropcova, B. et al. (2005) "Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor" Journal of Clinical Investigation — JCI24332 Used for: Formal definition of metabolic inflexibility — insulin-resistant muscle characterized by lower fasting lipid utilization and failure to switch to carbohydrate oxidation in response to insulin Sun, Q., Lopaschuk, G.D. et al. (2024) "Mitochondrial fatty acid oxidation is the major source of cardiac ATP production in heart failure with preserved ejection fraction" Cardiovascular Research, Volume 120 — PMID 38193548 Used for: Direct radiolabeled substrate measurements in HFpEF; suppressed insulin-stimulated glucose oxidation; increased FAO; decreased PDH phosphorylation confirmed in human heart samples; disrupted glucose/fat ATP balance Sun, Q., Karwi, Q.G., Wong, N., Lopaschuk, G.D. (2024) "Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond" Cardiovascular Research — PMC11646102 Used for: Comprehensive synthesis — decreased glucose oxidation as universal defect across HFpEF, HFrEF, and diabetic cardiomyopathy; uncoupling of glycolysis from glucose oxidation; FAO increases in HFpEF and diabetic cardiomyopathies Lopaschuk, G.D., Ussher, J.R., Folmes, C.D.L., Jaswal, J.S., Stanley, W.C. (2010) "Myocardial Fatty Acid Metabolism in Health and Disease" Physiological Reviews — PMC3976623 Used for: Fat oxidation dominance in HF, ischemia, and diabetes; uncoupling of glycolysis from glucose oxidation; therapeutic case for reducing FAO and increasing glucose oxidation (quotes carried over from Video 1 for context) Fillmore, N., Jaswal, J.S., Lopaschuk, G.D. (2011) "Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure" Journal of Molecular and Cellular Cardiology — ScienceDirect Used for: Pharmacological shifting from fat to glucose oxidation improving ATP efficiency; cardiac ischemia and heart failure therapeutic mechanism (context reference from Video 1) Satapati, S. et al. (2011) "Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease" Cell Metabolism — PMC3658280 Used for: 50% higher lipolysis in NAFLD; 30% higher gluconeogenesis; 2-fold increase in TCA cycle flux correlated with intrahepatic triglyceride content; increased FFA delivery and oxidation driving gluconeogenesis and oxidative stress Donnelly, K.L., Smith, C.I., Schwarzenberg, S.J., Jessurun, J., Boldt, M.D., Parks, E.J. (2005) "Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease" Journal of Clinical Investigation — JCI23621 Used for: Fat source breakdown in NAFLD — ~60% from plasma NEFA/adipose lipolysis, ~26% from de novo lipogenesis, ~15% dietary fat; stable isotope methodology confirming adipose lipolysis as primary driver Kolwicz, S.C. Jr. (2021) "Ketone Body Metabolism in the Ischemic Heart" Frontiers in Cardiovascular Me
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About Healthy AF | Healthy After 50
Healthy AF, the podcast dedicated to helping you live a healthier life after the age of 50, hosted by health and longevity expert Zane Griggs. This show is your guide to achieving optimal health, both physically and mentally. Whether you're in your 20s and want to plan for a healthy future or in your 50s and seeking to catch up, this show could help you improve your nutrition, fitness, and overall well-being. Each week, we'll dive into the latest research and expert advice on topics such as exercise, stress management, and more. We'll discuss practical strategies for maintaining a healthy lifestyle, including how to balance your diet and stay active as you age. Remember, it's never too late to prioritize your health and become Healthy AF!
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