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Cutting edge information on health and nutrition with Dr. Ben Weitz
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- Today43 min
The Biology of Skin Aging with Dr. Jessie Cheung: Rational Wellness Podcast 486
Skin Aging Beyond the Surface: Hormones, Metabolism, Mitochondria, and Regenerative Dermatology with Dr. Jessie Cheung Dr. Ben Weitz interviews board-certified dermatologist Dr. Jessie Cheung about skin aging as a reflection of systemic health, connecting skin, hair, and nails to nutrition, sleep, inflammation, hormones, metabolism, and regenerative biology. They discuss drivers of aging such as UV damage, pollution, stress, and hormone shifts, emphasizing menopause-related collagen loss and the importance of optimizing thyroid and sex hormones. Cheung shares perspectives on collagen support (including systemic and topical copper GHK), biostimulators (Sculptra, Radiesse), polynucleotides, exosomes, and laser/light therapies (red and near-infrared for mitochondria). They cover insulin resistance signs (acanthosis nigricans, skin tags), glycation from excess sugar, and GLP-1 agonists, including "Ozempic face," nutrition/protein focus, and microdosing approaches. The conversation also addresses maintaining muscle and bone density, sleep and diet priorities, key labs (vitamin D, ferritin, zinc, thyroid markers), avoiding overfilled aesthetics, and a root-cause approach to dermatology. 00:00 Podcast Intro 00:59 Skin As Health Mirror 02:25 Drivers Of Skin Aging 03:03 Hormones And Collagen 04:20 Peptides And Supplements 06:21 NAD And Longevity Stack 07:29 Practice Pillars And Joyspan 09:16 Insulin Resistance Signs 10:27 Glycation And GLP-1s 13:41 Microdosing And Gut Support 15:29 Mitochondria And Light Therapy 16:55 Sagging Skin Fixes 17:58 Muscle Building Devices 19:40 Root Cause Aesthetics 22:28 Biostimulators And Exosomes 24:14 PRP Regenerative Aesthetics 24:54 Overfilled Faces Fixes 26:15 Filler Risks And Dissolving 27:28 Sleep Supplements Protocol 28:57 Diet Vegetables And Fasting 32:11 Biomarkers For Skin Aging 34:36 Inside Out Functional Dermatology 37:00 Gut Skin Microbiome Talk 39:00 Hormones And Strength Aging Dr. Jesse Cheung is a board-certif
- 1 weeks ago1h 4m
Metabolic Psychiatry with Dr. Matthew Bernstein: Rational Wellness Podcast 485
View the Show Notes For This Episode Metabolic Psychiatry with Dr. Matthew Bernstein: Rational Wellness Podcast 485 Dr. Ben Weitz interviews psychiatrist Dr. Matthew Bernstein about metabolic psychiatry, proposing that some mental illnesses relate to brain energy metabolism, insulin resistance, and mitochondrial dysfunction rather than primarily neurotransmitter imbalance. Bernstein describes limits and side effects of conventional psychopharmacology and explains how brain insulin resistance can occur even with normal blood markers, especially in regions like the amygdala, hippocampus, and hypothalamus that use insulin-dependent GLUT4 transporters. He outlines how medical ketogenic diets may "rescue" brain energy by supplying ketones that cross the blood-brain barrier without insulin, reduce oxidative stress and inflammation, influence mitochondrial biogenesis, and shift GABA/glutamate balance. He discusses diet ratios, ketone monitoring, gradual transition and electrolyte support, conditions that may benefit, contraindications, medication reduction, lab testing (including carnitine), select supplements, and lifestyle factors such as exercise, mind-body practices, circadian rhythms, sleep, and gut health. 00:00 Show Intro and Mission 00:59 Metabolic Psychiatry Preview 02:40 Why He Shifted Beyond Meds 30:06 Low Carb vs Full Keto 31:27 Sample Keto Meals 33:42 Transition Tips and Keto Flu 36:00 Lasting Effects and Relapse Risk 38:16 Who Benefits Most 39:32 When Keto Is Not Fit 41:12 Reducing Psych Meds 42:34 Lab Workup Essentials 43:24 Iron Mitochondria Link 44:28 Carnitine Troubleshooting 46:38 Supplements That Help 47:33 Creatine And NAC Dosing 50:40 Low Dose Lithium 53:32 Mind Body Stress Tools 55:39 Gut Microbiome And Fiber 57:49 Sleep Circadian Reset 58:54 Resources And Wrap Up Dr. Matthew Bernstein is a psychiatrist and a leading voice in the emerging field of met
- 2 weeks ago55 min
The Ageless Revolution with Dr. Michael Aziz: Rational Wellness Podcast 484
Dr. Michael Aziz on Targeting Aging: Diet, Fats, Testing, Hormones, Peptides, and Practical Longevity Strategies Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews Dr. Michael Aziz about longevity and treating aging as a modifiable biological "syndrome," referencing the hallmarks of aging and the need for broad approaches because organs age at different rates. Aziz highlights major aging accelerators—processed foods, refined carbs/sugar, seed oils, poor sleep, and stress—criticizes low-fat guidelines and the Seven Countries study, and argues saturated fats (e.g., butter, coconut) are not the main driver of heart disease, which he frames as inflammation and oxidized/sticky cholesterol, emphasizing advanced lipid testing. He outlines a basic longevity lab panel (A1C, fasting insulin, hs-CRP, liver tests, advanced lipids) and discusses insulin resistance, GLP-1 drugs and side effects, muscle preservation, exercise/HIIT, and dietary moderation of grains and keto-style choices without processed meats. The conversation covers hormones, bioidentical replacement, peptides, senolytics (fasting, fisetin, quercetin, low-dose naltrexone), NAD/NR/NMN, supplements, sauna, tadalafil, metformin, and berberine. 00:59 Meet Dr Michael Aziz 02:51 Is Aging a Disease 04:14 Hallmarks of Aging 04:54 Measuring Biological Age 05:56 Biggest Aging Accelerators 06:18 Diet Pitfalls Sugar Oils 07:54 Keto Done Right 08:59 Saturated Fat Debate 12:37 Cooking Fats and Seed Oils 14:19 Low Fat Guidelines Myth 15:06 Vegetarian Diet Concerns 16:27 What Really Causes Heart Disease 18:01 Longevity Lab Testing 18:33 Insulin Resistance and GLP1s 19:31 GLP1 Side Effects 20:42 Muscle Mass for Longevity 21:08 Omega 6 Ratio Explained 22:21 Coconut Oil and Cholesterol 24:20 Perfect 10 Diet vs Keto 25:43 Whole Grains and Mediterranean Diet 27:52 Grains And Gluten 28:54 Mediterranean Vs French Diet 29:59 Dairy Benefits And Risks 30:39 Hormones And Aging 31:43 Peptides For Longevity 34:2
- 3 weeks ago55 min
Chronic Diarrhea: A Functional Medicine Approach w/ Dr. Ilana Gurevich Rational Wellness Podcast 483
Diarrhea: Root Causes, Testing, and Treatment Strategies with Dr. Ilana Gurevich Dr. Ben Weitz introduces the Rational Wellness Podcast episode on diarrhea and its complex differential diagnosis, featuring naturopathic gastroenterology specialist Dr. Ilana Gurevich. They discuss defining diarrhea using the Bristol Stool Chart and distinguishing acute from chronic cases, including when to investigate (about 4–5 days for new onset). Gurevich outlines an acute workup using LabCorp's rapid GI Pathogen Profile PCR stool test, notes limitations and false positives, and explains her approach to chronic diarrhea evaluation, including GI-MAP with optional bile acid testing (OMX), pancreatic elastase and steatocrit for fat malabsorption, and assessment for SIBO/SIFO and H. pylori (emphasizing conventional confirmation and virulence factors). They cover bile acid malabsorption and treatment with bile acid sequestrants and fibers, exocrine pancreatic insufficiency and enzyme dosing, microscopic colitis requiring diagnostic colonoscopy biopsies and budesonide, carbohydrate malabsorption breath testing, hydrogen sulfide SIBO uncertainty, the role of stress/nervous system and motility, and supplement causes like excess magnesium or vitamin C. 00:00 Podcast Intro 00:59 Why Diarrhea Is Complex <div class="stack gap-1" style= "border: 0px solid rgb(229, 231, 235); box-sizing: border-box; display: flex; flex-direction: column; gap: 4p
- 4 weeks ago1h 23m
An Integrative Approach to Parkinson's Disease with Dr. Karin Duncan | Rational Wellness Podcast 482
An Integrative Approach to Parkinson's: Gut-Brain Axis, Toxins, Pro21 Diet, Testing & Key Supplements | Dr. Karin Duncan Dr. Ben Weitz introduces a Rational Wellness Podcast episode on Parkinson's disease with naturopathic physician Dr. Karin Duncan, who is launching the Integrative Neurology Wellness Center in Hayden, Idaho in partnership with the Northwest Parkinson's Foundation to provide accessible integrative care. They discuss Parkinson's as more than dopamine deficiency, emphasizing toxins, inflammation, mitochondrial dysfunction, oxidative stress, and the gut-brain axis, with increasing young-onset cases. Duncan explains clinical diagnosis, limits of DaTscan, and her reliance on the CND/Syn-One skin biopsy for alpha-synuclein. They cover prodromal symptoms (constipation, loss of smell, REM sleep behavior disorder), alpha-synuclein and Lewy bodies, and her evaluation approach including nutrient and inflammatory labs, omega-3/6 targets, iron, thyroid/hormones, microbiome testing, and caution with detox. They review ProPD symptom tracking, Pro21 diet (avoid dairy, beef/pork/chicken, fried/refined/canned foods), exercise, glutathione, DHA, low-dose lithium, vitamin D/K2, LDN, and careful use of methylene blue, plus community and mental health support. Dr. Laura Mischley's Pro 21 diet was published: Beyond MIND and Mediterranean Diets: Designing a Diet to Optimize Parkinson's Disease Outcomes. Laura Mischley's Parkinson's symptom tracking (Pro-PD) app can be found here: lauriemischley.com/pro-pd-app 00:00 Podcast Intro 01:02 Parkinsons Overview 02:30 New Clinic Foundation 04:41 Toxins Call to Action 07:41 Young Onset Cases 08:37 Diagnosis Testing Tools 12:49 Prodromal Warning Signs 14:44 REM Sleep Explained 16:32 Constipation Mechanisms 20:29 Alpha Synuclein Gut Brain 24:25 Tracking Symptoms ProPD 29:28 Lewy Bodies Basics 30:07 Integrative Lab Workup 31:45 Methylene Blue Safety 34:02 Omega Fats Targets 36:50 Iron Thyroid Hormones 38:38 Gut Testing Dysbiosis 39:59 SIBO Testing Alternatives 41:28 Microbiome Testing Roadmap 43:47 Stool Tests and Gut Function 46:02 Diet Strategy and Pro 21 48:57 Pro 21 Foods to Avoid 51:09 Toxins and Detox Caution 53:13 Supplements That Move the Needle 59:58 Probiotics Targeted Not Empirical 01:01:24 Exercise and Realistic Outcomes 01:04:15 High Tech Therapies and Palliation 01:05:33 Methylene Blue Safety and Dosing 01:08:45 LDN and Mental Health Support 01:11:25 Tremors Vagus Nerve and DBS 01:13:10 Build Your Care Team 01:15:09 Resources and How to Connect Karin Duncan is a naturopathic physician who recently launched her new office, the Integrative Neurology Wellness Center in Hayden, Idaho in partnership with the Northwest Parkinson's Foundation to provide accessible integrative care to patients with neurodegenerative disorders. Her website is the Integrative Neurology Wellness Center and her phone is 208-480-4692. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure. Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.
- Sep 29, 202653 min
The HRT Questions Most Women Never Get Answered with Karen Martel | Rational Wellness Podcast 481
The HRT Questions Most Women Never Get Answered with Karen Martel | Rational Wellness Podcast 481 Perimenopause to Menopause: Testing, Progesterone First, and Evidence-Informed HRT with Karen Martell Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews hormone specialist Karen Martell about perimenopause and menopause, emphasizing that midlife hormonal shifts affect metabolism, sleep, mood, cognition, bone and cardiovascular health. Martell says perimenopause can begin in the mid-30s, often with declining progesterone from less frequent ovulation, leading to heavy periods, insomnia, anxiety, and perceived "estrogen dominance," while estrogen later becomes erratic and then declines toward menopause around age 51. She critiques common responses like birth control, hysterectomy, and symptom-only medications, and recommends combining bloodwork with saliva or urine metabolite testing (e.g., DUTCH) when cycling. For HRT, she prefers transdermal estradiol over oral estrogen, discusses progesterone delivery options and sensitivities to oral metabolites, addresses testosterone (often compounded; injectable preferred), and notes roles for DHEA and pregnenolone. She also covers vaginal therapies, dosing based on both symptoms and protective lab ranges, and cautious later-life initiation. 00:00 Show Intro and Mission 00:59 Why Midlife Hormones Matter 02:23 Perimenopause Starts Early 03:18 Progesterone Drop Signs 06:17 Testing Hormones and Thyroid 08:02 Bad Advice and Quick Fixes 09:33 When Supplements Aren't Enough 10:52 Starting Progesterone Therapy 12:49 Best Hormone Testing Methods 15:36 Endocrine Disruptors Cleanup 17:40 Choosing Estrogen Delivery 18:43 Pellets and Testosterone Risks 22:27 Progesterone Forms and Dosing 25:21 Why Avoid Oral Estrogen 27:00 Estradiol for Life 27:38 Estriol vs Estradiol 30:23 Patch vs Cream Dosing 31:56 E4 Estrogen Debate 33:39 Cycling Progesterone 35:38 DHEA and Pregnenolone 37:39 Vaginal Hormone Options 40:18 Optimizing HRT Levels 43:52 Starting HRT After 70 47:45 Perimenopause Timing Tips 50:19 Where to Find Karen <!--
- Sep 24, 202658 min
What are the Functions of Microbial Gases, Hydrogen, Methane, & Hydrogen Sulfide with Dr. Tom Fabian | Rational Wellness Podcast 480
What are the Functions of Microbial Gases, Hydrogen, Methane, & Hydrogen Sulfide with Dr. Tom Fabian | Rational Wellness Podcast 480 Gut Microbial Gases Beyond SIBO: Hydrogen, Methane, and Hydrogen Sulfide as Signaling Metabolites Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews Dr. Tom Fabian, PhD, to discuss gut microbial gases beyond the usual SIBO framing. They explain that hydrogen, methane, and hydrogen sulfide are normal microbial metabolites with potential signaling roles, alongside key microbiome products like short-chain fatty acids (especially butyrate), which fuels colon cells, supports tight junctions, regulatory T cells, and helps maintain an anaerobic colon environment. Fabian notes metabolomics (e.g., GI-MAP stool add-ons) can provide functional insight beyond which microbes are present, highlighting butyrate producers such as Faecalibacterium and Roseburia. They review controversies in breath testing interpretation, discuss methane biology and debated links to constipation, and emphasize emerging research that hydrogen sulfide is widely produced (often from cysteine metabolism), supports colon mitochondria and anaerobiosis, may relate to stress responses and longevity, and that excessive sulfur restriction may be misguided; fiber and polyphenols may mitigate protein-driven hydrogen sulfide. 00:00 Show Intro 00:59 Why Gut Gases Matter 04:04 Microbiome Metabolites 05:52 Butyrate Deep Dive 09:07 Measuring SCFAs 13:20 Hydrogen and Breath Tests 19:12 Hydrogen Benefits 28:19 Methane and Motility 31:06 Sponsor Break 32:13 Methanogens Explained 35:24 Hydrogen Sulfide Science 50:59 Clinical Takeaways Dr. Tom Fabian has a PhD in molecular biology and who has spent many years researching the microbiome and translating the scientific literature into practical applications for functional medicine practitioners. Currently, Dr. Fabian serves a consultant and science advisor with Diagnostic Solutions Laboratory. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure. Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.
- Sep 19, 202659 min
Removing Galectin 3 to Prevent Sepsis and Chronic disease with Dr. Isaac Eliaz | Rational Wellness Podcast 479
Galectin-3, Modified Citrus Pectin, and Therapeutic Apheresis: Emerging Applications in Sepsis, Cancer, and Chronic Inflammation Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews returning guest Dr. Isaac Eliaz about galectin-3 as an upstream driver of inflammation and fibrosis implicated in chronic degenerative disease, autoimmunity, cancer progression, and acute sepsis. Eliaz explains modified citrus pectin (PectaSol) as a researched galectin-3 inhibitor, discusses dosing ranges, and describes its clinical relevance across inflammation, cardiovascular risk, microbiome effects, and cancer (including prostate cancer trials). The conversation focuses on therapeutic apheresis and plasma exchange, contrasting nonselective plasma exchange with selective approaches such as LDL apheresis and Eliaz's developing Xgal-3 filter designed to remove circulating galectin-3. He cites porcine sepsis data, an FDA breakthrough designation, upcoming sepsis trials, and potential to enhance cancer immunotherapy, while warning about hype, safety, training, and misuse in integrative settings. 00:00 Show Introduction 00:59 Meet Dr Isaac Eliaz 02:47 What Is Galectin 3 09:25 Galectin 3 And Sepsis 11:45 Modified Citrus Pectin Basics 17:11 MCP Dosing Guide 20:43 MCP Gut And Cancer Research 25:33 Why Galectin 3 Is Overlooked 26:49 Apheresis Filter Breakthrough 28:57 Will Galectin 3 Return 29:49 Sepsis Immune Overdrive 30:39 Galectin-3 Cancer Shield 31:13 MCP Prostate Trial Wins 33:33 Boosting Immunotherapy Response 35:32 Therapeutic Apheresis Explained 36:48 Plasma Exchange Hype Risks 39:12 Safer Protocols And Expertise 47:02 Personal Longevity And LDL 49:53 Selective Vs Plasma Outcomes 52:59 Future Trials And Wrap Up Dr. Isaac Eliaz is an internationally recognized expert in the field of integrative medicine. A highly skilled physician and healer trained across diverse medical systems, Dr. Eliaz offers an unparalleled holistic approach to health and healing. He is a leading specialist in integrative cancer treatment and prevention, mind-body medicine, and
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