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Fractals: Life Science Conversations: Daily Summaries Delivered
by The Bracken Group
Insightful, informative, and warmly good-humored, Fractals features life sciences leaders sharing wisdom, career highs and lows, and compelling stories from the intersections of clinical development, health care, and technology. Presented by The Bracken Group.
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- 6 days ago39 min
Operation TrialBlazer: Turning Policy into Progress with Guest Rob King
A roadmap can set the direction. What actually gets a clinical trial moving?In this episode of Fractals: Life Science Conversations, Rob King of Pivotal CRO joins Colin Miller to unpack Operation TrialBlazer—and ask whether its ambitions address the practical barriers slowing U.S. clinical research.With more than 30 years of experience across CROs, biotech, government, and academia, Rob brings a global perspective to the discussion:Why sponsors look beyond the U.S. for early-phase trialsHow site contracting can undermine efforts to accelerate developmentWhy eligibility criteria deserve scrutiny before a protocol is finalizedWhere CROs need to challenge sponsors and contribute earlierHow sponsors can distinguish actionable changes from proposals still taking shapeA candid conversation about what it takes to turn policy ambitions into progress for sponsors, sites, and patients.
- Sep 11, 202635 min
Decoding the Real-World Language of Healthcare with Guest Jo Halliday
Life sciences doesn’t have a data problem. It has a making-sense-of-the-data problem.In this episode of Fractals: Life Science Conversations, Jo Halliday, CEO and Founder of Talking Medicines, joins host Colin Miller to explore how AI, natural language processing, and real-world signals can help life science organizations better understand what patients and healthcare professionals are actually saying—and turn those insights into better decisions.From the episode:Why unstructured healthcare conversations can reveal insights traditional datasets missHow Talking Medicines evolved from collecting first-party patient data to analyzing signals across multiple sourcesWhat rapidly changing GLP-1 conversations tell us about increasingly informed and empowered patientsHow message resonance and behavioral trends can help pharma determine whether its communications are actually moving the needleWhy the future of AI in life sciences will be less about the technology itself—and more about the questions it can help answer
- Aug 12, 202631 min
Beyond the Snapshot: Imaging Biology in Motion with Roughan Sheedy & Beth Fisher
Imaging has traditionally been used to document what (already) happened. What if it could help determine what happens next? On the newest episode of Fractals, Colin Miller is joined by Fidēs Imaging CEO Roughan Sheedy and Head of Women’s Health Beth Fisher to discuss how advanced imaging can support earlier, sharper development decisions. They explore: Why early-phase programs need more than standardized endpoints How imaging biology in motion can uncover previously invisible phenomena Where dynamic imaging may add value across GI disease, women’s health, fibrosis, inflammation, and solid tumors What it will take for emerging imaging endpoints to earn regulatory credibility
- Jul 8, 202633 min
Beyond Pain Management: A One Medicine Approach to Osteoarthritis with Guests Graham Lumsden and Jonathan Larkin
What happens when human health, animal health, and entrepreneurial drug development intersect? In this episode of Fractals: Life Science Conversations, Bracken CEO Colin Miller is joined by Senior Partners Graham Lumsden, BVM&S, Dip.M., MRCVS, and Jonathan Larkin, PhD, to discuss osteoarthritis innovation, One Medicine, and the collaborative pathways that can move novel therapies forward. Together, they discuss: Why osteoarthritis remains a major unmet need in both human and animal health How disease-modifying approaches could shift treatment beyond pain management The promise of bispecific antibody development in addressing both pain and cartilage degeneration How animal health studies can help inform human development programs, and vice versa Why human expertise, networks, and scientific judgment remain essential in the age of AI Tune in to Fractals on your preferred podcast platform, and reach out to Bracken to learn how we help life science teams connect strategy, science, and execution across development.
- Apr 7, 202633 min
From Simulation to Scale: Rethinking Pharmaceutical Coating with Guest Dr. Michael Choi
Pharmaceutical manufacturing still struggles with a fundamental challenge: turning complex science into reliable, scalable, real-world processes. Dr. Michael Choi has spent his career solving exactly that. As Founder of PCTS and a pioneer in tablet coating simulation, Michael has developed tools that bring clarity to one of the most complex—and often misunderstood—steps in drug production. In this episode of Fractals: Life Science Conversations, Michael and host Colin Miller discuss: The hidden variability behind coating uniformity, and why probability sits at the core of the process How small, overlooked variables (like minor temperature shifts) can drive major manufacturing failures Why “more advanced” technology doesn’t always mean better outcomes without grounding in fundamentals The growing gap between sophisticated modelling tools and the teams who need them most How digital twins, continuous manufacturing, and AI could converge to transform production over the next decade At its core, this episode is about making science usable: bridging theory and execution to deliver better outcomes across the product lifecycle. Listen now on your preferred platform—and connect with Bracken to learn how we help translate complex science into actionable strategy.
- Feb 4, 202621 min
From Baby Feeding to Better Outcomes: Building Virtual, Preventive Maternal Care with Guest Cory Wyman
What if maternal care was a proactive partner in your baby’s development, not just stepping in at a point of crisis?On this episode of Fractals, Cory Wyman, Director of Marketing at SimpliFed, joins Colin Miller to unpack how virtual lactation and baby-feeding support can reshape maternal health: clinically, emotionally, and economically.From the episode:Why baby feeding is often the first point of contact in postpartum careHow virtual care creates deeper honesty and stronger provider-patient trustThe link between feeding challenges and maternal mental healthWhy screening at every appointment changes outcomesHow SimpliFed aligns value-based outcomes for payers, employers, and familiesWhat tech-enabled provider services get right that standalone apps missCory also shares a compelling vision for the future of maternal health—where digital tools are directly connected to real providers, not left to parents to interpret alone.Listen to Fractals on your favorite podcast platform, and connect with Bracken to learn how we support life science and digital health organizations.
- Jan 7, 202629 min
Imaging, Trust, and the Real-World: The Current State of Radiopharmaceuticals with Dr. Deepak Behera
With more than two decades of experience spanning clinical practice, translational research, and global industry leadership, Bracken Senior Partner Dr. Deepak Behera has actively shaped how radiopharmaceuticals are developed, evaluated, and delivered to patients. As President and CEO of Adaptive Research and Senior Partner at Bracken, Deepak is an expert in connecting science, strategy, and real-world execution.In this episode of Fractals: Life Science Conversations, Deepak and host Colin Miller discuss:Why imaging is more than visualization, and how it functions as a powerful biomarker in theranosticsWhen diagnostics should stand on their own, rather than being treated as a secondary companion to therapyHow imaging-only studies can uncover unexpected biology and sharpen indication strategy earlyThe operational, economic, and educational realities that determine whether radiopharmaceuticals succeed post-approvalWhy multidisciplinary skill sets—not linear career paths—are essential for the next generation of radiopharma leadersTune in to Fractals on your preferred podcast platform, and reach out to Bracken to learn how we help sponsors navigate imaging-driven development and radiopharmaceutical strategy with confidence.
- Nov 19, 202533 min
Beyond Baby Steps: Transforming Maternal Health with Guest Mary Hardy
Mary Hardy, Chief Commercial Officer at SimpliFed, is helping reshape maternal health care with a virtual platform that supports families before birth and well beyond the baby’s first milestones. By combining lactation guidance, postpartum care, maternal mental health screening, and remote monitoring, SimpliFed is setting a new standard for holistic, accessible maternal care.In this episode of Fractals: Life Science Conversations, Mary joins host Colin Miller to explore:How SimpliFed’s virtual care model bridges gaps in maternal health, particularly in underserved areas and for mobile families.The integration of prenatal planning, postpartum support, and behavioral health referrals to improve both outcomes and patient experience.Leveraging technology and human relationships together to deliver personalized care at scale.Insights from Mary’s journey in healthcare, and her vision for embedding community and connection into maternal care.Tune into Fractals on your preferred podcast platform, and contact Bracken to discover how our cross-functional teams support life science and digital health solutions.
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About Fractals: Life Science Conversations
Insightful, informative, and warmly good-humored, Fractals features life sciences leaders sharing wisdom, career highs and lows, and compelling stories from the intersections of clinical development, health care, and technology. Presented by The Bracken Group.
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