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by Andreessen Horowitz
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm.
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- 2 days ago1h 1m
Mark Cuban’s Plan to Make Healthcare Affordable
Mark Cuban thinks AI could transform healthcare, but it won’t fix opaque prices and broken incentives on its own. His starting point for employers: run every benefits contract through AI and ask where you’re getting ripped off.Mark joins a16z General Partner Julie Yoo and Erik Torenberg to discuss what he’s learned building Cost Plus Drugs, why trust is its core product, and how greater transparency could put pressure on healthcare costs.They also explore where AI can help, what personalized medicine could look like, how the role of doctors may change, and why Mark believes founders should use AI to learn, not as an excuse to stop thinking.Resources:Follow Mark Cuban on X: https://x.com/mcuban Follow Julie Yoo: https://x.com/julesyoo Mark Cuban Cost Plus Drug Company: https://costplusdrugs.com/Cost Plus Wellness: https://costpluswellness.com/ Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
- 3 days ago56 min
Reinventing School for the AI Era | Joe Liemandt, Gagan Biyani & Erik Torenberg
What should school look like if AI can help students learn dramatically faster? Alpha School founder Joe Liemandt argues the answer isn’t to fill the extra time with more academics, but to redesign school around the skills traditional classrooms struggle to teach: agency, teamwork, entrepreneurship, communication, and doing hard things.Joe joins Erik Torenberg and Horowitz and Andreessen Academy co-founder Gagan Biyani to discuss Alpha’s model, where students spend two hours a day on core academics and the rest developing real-world skills through projects. They explore what that approach can teach higher education, why motivation may matter more than curriculum, and how HAA is applying similar principles to college-age students by putting building, relationships, and real-world experience at the center of the learning experience. They also discuss what parents need to believe before choosing a new educational model, why Joe expects AI to drive an explosion in entrepreneurship, and why the most important question for students may not be which field is safest from AI, but what they care enough about to build. Resources:Learn more about Horowitz and Andreessen Academy: https://www.theacademysf.com/ Learn more about Alpha School: https://alpha.school/joe-liemandt-and-the-future-of-education/ Follow Joe Liemandt on X: https://x.com/jliemandt Follow Gagan Biyani: on X https://x.com/gaganbiyani Follow Erik Torenberg on X: https://x.com/eriktorenberg Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
- 4 days ago45 min
OpenAI: When AI Agents Use Computers Faster Than You
AI agents are approaching a point where they can use computers faster than expert humans, turning the user interface itself into a universal way for AI to interact with software. OpenAI’s Ari Weinstein and James Sun argue that computer use is now entering its scaling moment, as better models, faster execution, and stronger safety controls make agents practical for more consumer and enterprise work.Ari and James join a16z’s Seema Amble and Fabrizio Serafini to explain how computer-using agents are already navigating legacy ERPs, reconciling financial data, handling procurement, and operating software without APIs or custom integrations. They also discuss why the harness around the model can matter as much as model intelligence, how enterprises can set deterministic guardrails around agent behavior, and why computer use could simultaneously extend the life of legacy software and accelerate the arrival of new AI-native applications. Looking ahead, they make the case for a more proactive and fluid relationship with computers, where agents work in the background, collaborate with users in real time, and increasingly adapt to us rather than requiring us to learn how to use them.Resources:Follow Seema Amble on X: https://x.com/seema_amble Follow Fabrizio Serafini on X: https://x.com/fabserafini Follow Ari Weinstein on X: https://x.com/AriX Follow James Sun on X: https://x.com/JamesZmSun Related a16z research from Seema Amble and Fabrizio Serafini: Can Agents Use a Computer Yet? We’ve Got the Data Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
- 5 days ago34 min
The New Startup Playbook | Box CEO Aaron Levie
Can a 10-person startup outperform a company with hundreds of employees? Box CEO Aaron Levie argues AI agents are giving small teams a level of leverage that simply wasn't economically possible before, creating a window for startups to outrun incumbents.In this episode of Speedrun Office Hours, Aaron explains why founders are shifting from doing the work themselves to orchestrating agents, and why that puts a new premium on strategy, taste, and knowing exactly what to build. He makes the case that nearly every industry and job function could support specialized AI agents, potentially creating hundreds of new billion-dollar companies.They also discuss why enterprise AI may capture much of the next wave of model improvements, how dramatically cheaper AI labor could unlock demand that doesn't exist today, and one thing Aaron thinks AI won't change: distribution. If you build it, they still won't necessarily come. Resources:Watch the original Speedrun Office Hours episode: https://www.youtube.com/watch?v=wZ1joGIUyK8Learn more about Speedrun: https://speedrun.a16z.com/Follow Speedrun on X: https://x.com/speedrunFollow Aaron Levie on X: https://x.com/levie Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
- 6 days ago41 min
What It Takes to Win as a Founder | Ben Horowitz
What does it take to build a company when AI is changing the rules this quickly? Ben Horowitz argues that technology may make companies easier to start, but the hardest parts of entrepreneurship, making decisions under uncertainty, building momentum, and managing your own doubts, aren't going away.Speedrun's Andrew Chen sits down with Ben to discuss why AI feels different from previous technology shifts, whether billion-dollar companies can be built with tiny teams, and why Ben thinks the application itself may eventually become less important as agents work directly against data.They also get into defensibility in AI, what founders should look for in an investor, how venture capital is changing, and why the best entrepreneurs aren't defined by a lack of weaknesses, but by having a strength or insight that's genuinely exceptional. Resources:Follow Ben Horowitz on X: https://x.com/bhorowitzFollow Andrew Chen on X: https://x.com/andrewchenLearn more about Speedrun: https://speedrun.a16z.com/apply Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
- 1 weeks ago1h 1m
Amazon CEO Andy Jassy on Why Amazon Is Investing $220 Billion in AI
Amazon expects to spend roughly $220 billion in CapEx in 2026, yet CEO Andy Jassy says the company is still leaving meaningful AI demand on the table.** He believes the buildout could ultimately help make AWS a $1 trillion annual run-rate business.Andy joins a16z co-founder Ben Horowitz and Erik Torenberg to discuss why AI demand is growing so quickly, how Amazon decides how much infrastructure to build, and why lower inference costs could unlock broader enterprise adoption.They also discuss how AI is reshaping Amazon itself, from smaller teams building products faster to reimagining Alexa, and why Andy sees cybersecurity, human judgment, and critical thinking as increasingly important in the AI era. Resources:Follow Andy Jassy on X: https://x.com/ajassy Follow Ben Horowitz on X: https://x.com/bhorowitz Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
- 1 weeks ago1h 1m
The Frontier Ideas a16z Wants to Fund | Marc Andreessen, Ben Horowitz & Chris Dixon
a16z is expanding a16z crypto into a16z Frontier, a broader mandate to back founders building at the edges of what's possible. Chris Dixon joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to explain why founders should increasingly ask not “is this too ambitious?” but “is this ambitious enough?” — and how AI could pull decades of technological progress forward across hardware, robotics, entertainment, science, and entirely new forms of media.They also explore the coming internet of AI agents, why open source matters as AI becomes more powerful, and why some of the most important companies of the next decade may combine technologies and business models that previously belonged in separate categories.Resources: Follow Chris Dixon on X: https://x.com/cdixonFollow Marc Andreessen on X: https://x.com/pmarcaFollow Ben Horowitz on X: https://x.com/bhorowitz Learn more about a16z Frontier: https://a16zfrontier.comhttps://a16zfrontier.substack.comhttps://x.com/a16zfrontier Stay Updated:If you enjoyed this episode, be sure to like, subscribe, and share with your friends!Find a16z on X: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zListen to the a16z Show on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYXListen to the a16z Show on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see http://a16z.com/disclosures. Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
- 1 weeks ago38 min
The Missing Infrastructure for AI Agents: Documents | Reducto’s Adit Abraham
AI agents can reason over enormous amounts of information, but much of the world’s actual work is still trapped in PDFs, spreadsheets, scans, and other formats that models struggle to reliably understand. Reducto co-founder and CEO Adit Abraham argues that solving this document layer is essential if agents are going to take on consequential work in healthcare, legal, finance, and insurance.Adit joins a16z General Partner Jennifer Li to explain why traditional OCR breaks down on messy real-world documents, how Reducto combines vision-language models with specialized infrastructure to reach high accuracy without sacrificing cost or latency, and why frontier models can silently drop information on long extraction tasks. Reducto now processes billions of pages each month, including its seven billionth page the morning of the recording. They also discuss Reducto’s R1 model, agents that can review and correct their own document extraction, and the company’s push beyond simply reading files toward letting agents reliably work with and edit them. Underneath it all is a higher-stakes problem: when a misread word can affect a healthcare claim or financial decision, getting the input right matters just as much as making the model smarter.Resources:Learn more about Reducto: https://reducto.aiFollow Adit Abraham on X: https://x.com/aditabrm Follow Jennifer Li on X: https://x.com/JenniferHli Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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About The a16z Show
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm.
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