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Pharm to Table: Daily Summaries Delivered
by LC Campeau, Dani Schultz
A podcast hosted by L.-C. Campeau and Dani Schultz that dives into the stories about the people behind the chemistry and science that happens at #MerckChemistry.
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- 1 weeks ago30 min
SE5:E5 - Part 2: Protecting Groups? We Need to Talk: Manufacturing MK-0616 with Enzyme Cascades
Part 1 laid out the strategy. Now, it’s time to make the molecule. Four enzymes, one vessel, and plenty of competing amines. What could possibly go wrong? Dani and LC return with Stephanie Galanie, Director in Biocatalysis, and Artis Klapars, Distinguished Scientist in Process Chemistry, for a closer look at the chemistry behind MK-0616 manufacturing.We start with the northern fragment, where making three bonds selectively means getting four engineered enzymes to play well together, ATP recycling included. Then we tackle fragment ligation with an evolved thioesterase and a hydrogen-borrowing cascade that closes a macrocycle. How do you drive an uphill reaction toward completion? And why would you start engineering an enzyme with the “wrong” substrate? Stephanie and Artis explain the solutions behind the synthesis.Finally, traditional coupling chemistry gets its moment alongside enzymatic macrocyclization, and a “counterion dance” gets MK-0616 out of solution in the right purity and salt form. We wrap up with what it takes to turn ambitious chemistry into a manufacturing process, and why protecting-group-free fragment coupling, concentrated macrocyclizations, and crystallization could change how we make complex peptides.Read some of the papers we discussed today:Biocatalytic cascades enable manufacture of the macrocyclic peptide MK-0616 - ScienceFollow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
- 1 weeks ago30 min
SE5:E4 - Part 1: Protecting Groups? We Need to Talk: Manufacturing MK-0616 with Enzyme Cascades
How do you design a manufacturing process for a molecule as complex as MK-0616? In Part 1 of this Pharm to Table series, Dani and LC join Stephanie Galanie, Director in Biocatalysis, and Artis Klapars, Distinguished Scientist in Process Chemistry, to discuss the manufacturing route behind their Science paper on biocatalytic cascades for this macrocyclic peptide.We start with a central question: why develop a new synthesis when an existing route already delivers hundreds of kilograms? Artis and Stephanie explain how the team worked backward from MK-0616’s complex structure to choose key disconnections, then developed three interconnected cascades to assemble it. Along the way, we unpack the tools behind those decisions, including directed evolution and enzymes that selectively form amide bonds without relying on protecting groups.Part 2 takes us inside the cascades, from four enzymes working in one vessel to fragment ligation and macrocyclization, then tackles the final challenge: isolating MK-0616 in the right purity and salt form.Read some of the papers we discussed today:Biocatalytic cascades enable manufacture of the macrocyclic peptide MK-0616 - ScienceFollow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
- Aug 11, 202634 min
SE5:E3: A Process Chemist's Romance with Scaling a Macrocyclic Peptide
Last episode, we watched medicinal chemistry dream up enclitide (MK-0616) — this week we find out what happens when someone actually has to make it. Dani and LC are joined by David Thaisrivongs and Gao Shang to unpack their recent JACS paper on the total synthesis of enlicitide, a macrocyclic peptide complex enough to keep company with taxol, vancomycin, and eribulin. Along the way they get into the pivot from solid-phase to solution-phase peptide synthesis, the perpetual headache of sourcing non-canonical amino acids and how biocatalysis cracked it open, and the crystallization detective work that let the team ditch chromatography entirely. There's also a great discussion on why a late-stage macrolactamization became a late-stage RCM — the kind of route decision that looks obvious only in hindsight. Fair warning: this one was among JACS's top-accessed papers of 2025, so you're in good company!If you enjoyed this chapter of the enlicitide story, stay tuned—we've got plenty more peptide chemistry, process development adventures, and behind-the-scenes drug discovery stories coming your way this season.Read some of the papers we discussed today:Total Synthesis of Enlicitide Decanoate - J. Am. Chem. Soc.Follow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
- Jul 15, 202626 min
SE5:E2: The Macrocyclic Mullet: The Story of Enlicitide
What happens when the textbook SAR playbook stops working? On this episode of Pharm to Table, Rob Garbaccio joins Dani and LC to share the discovery story behind enlicitide (MK-0616), a journey filled with unusual SAR, creative problem-solving, and plenty of chemistry twists along the way. From issue-driven drug design to non-canonical amino acids and modular synthesis strategies, this conversation offers a behind-the-scenes look at how real medicines are discovered. If you're training as a chemist today, this is a story you won't want to miss.If you enjoyed this chapter of the enlicitide story, stay tuned—we've got plenty more peptide chemistry, process development adventures, and behind-the-scenes drug discovery stories coming your way this season.Read some of the papers we discussed today:Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR - J. Med. Chem.Follow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
- May 18, 202641 min
SE5:E1 - A Journey of Synthetic Chemistry Innovations at Merck
To kick off Season 5, Dani and LC discuss a recent perspective published in the Journal of Organic Chemistry that highlights innovations in synthetic chemistry which trace their origins to the work of discovering, developing and commercializing novel therapeutics. This publication was the most accessed paper published in JOC in 2025!Dani and LC explore the motivations on writing it, its main thesis and lesson learned from reexamining nearly 75 years of chemistry innovations at Merck. Be sure to listen through to the very end for a special Season 5 theme reveal!Read and listen to some of the papers we discussed today:From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at MerckFollow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
- Mar 23, 202631 min
SE4:E8: From Discovery to Process, Part 2: Getting Ugi with it - scaling a 3CL protease inhibitor
In Part 2 of our Pharm to Table deep dive on MK‑7845, Dani and LC shift from invention to implementation, welcoming process chemists Nastaran Salehi Marzijarani and Ben Turnbull to the pod. We explore how the team re‑imagined the synthesis to enable robust, scalable supply—and why a classic multicomponent reaction you probably remember from school, the Joullié–Ugi reaction, ended up stealing the show. Along the way, we unpack route selection trade‑offs, lifecycle thinking in process chemistry, and what it really takes to bring an antiviral to life at scale. Read and listen to some of the papers we discussed today:Asymmetric Synthesis of MK-7845, an Investigational Treatment for COVID-19 - Org. Lett.Part 1 of MK-7845 series: SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design IntuitionFollow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
- Feb 2, 202629 min
SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
In this first installment of our two‑part Pharm to Table special on MK‑7845, Dani and LC sit down with medicinal chemist Valerie Shurtleff to unpack the discovery journey behind this 3CL protease inhibitor—from early structural insights to an unexpectedly effective difluorobutyl isostere. Val walks us through how the team balanced potency, VLE, metabolic challenges, and design intuition to land on a well‑rounded preclinical candidate - one of the most dynamic programs of her career. Along the way, she reminds us why asking good questions, collaborating relentlessly, and occasionally surviving a “Hot Ones” challenge are all essential scientific skills. It’s an episode packed with chemistry, creativity, and just enough fluorine to keep things spicy.Stay tuned for Part 2, where we shift from invention to implementation and explore how the process chemistry team brought MK‑7845 to life at scale.Read some of the papers we discussed today:Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic - J. Med. Chem.Follow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
- Nov 10, 202530 min
SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
Join us for a conversation with Yining Ji Chen, recipient of the 2025 ACS Rising Star Award, on how mechanistic insight powers innovation in pharmaceutical process research. We dive into her career journey and standout projects—from Pd-catalyzed C–N coupling for HCV therapy to dynamic phosphorylation in nucleotide synthesis—plus her creation of LED‑NMR for real-time photochemical reaction monitoring. Hear how deep mechanistic understanding drives robustness and safety, why she moved to the Data‑Rich Measurements group, and which emerging analytical technologies excite her most. A celebration of scientific rigor shaping efficient, reliable pharma processes!Read some of the papers we discussed today:A multifunctional catalyst that stereoselectively assembles prodrugs - ScienceA rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions - Chem SciLED-Illuminated NMR Spectroscopy: A Practical Tool forMechanistic Studies of Photochemical Reactions - ChemPhotoChemFrom at-line to online NMR: coupling probe-based autosampler with benchtop NMR - Reaction Chemistry and EngineeringFollow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
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